Liver and gut co-relation with liver disorders and diabetes
As studies confirm that diabetic patients are prone and have high prevalence of liver disorder and patients with liver disease are more inclined towards diabeties.1 So liver disorder should not be taken lightly at any instance. Here we will try to understand few questions regarding liver disorder and its relation with gut and its microbiome.
The liver plays a key role in regulating both glucose and lipid metabolism, derangements of which occur in NAFLD (non-alcoholic fatty liver) and T2D (type 2 diabetes). In T2D, fasting hyperglycemia results from unopposed endogenous glucose production due to IR (insulin resistance) and postprandial hyperglycemia from the inability to store glucose as glycogen after a meal. Both fasting and postprandial hyperglycemia are, at least in part, linked to the amount of hepatic steatosis(abnormal retention of fat (lipids) within a cell or organ). 6
Generally we are under impression that high fat diet and sugar containing products is cause of Non-alcoholic fatty liver but things are more than that, studies show that along with over nutrition and a sedentary lifestyle, high in sugar (from sucrose and/or high-fructose corn syrup [HFCS]) not only increase the risk of NAFLD, but also non-alcoholic steatohepatitis (NASH).
Recent evidence suggests that the predisposition to fatty liver is linked uric acid generation that mediate fat accumulation. The liver and intestine communicate extensively through the biliary tract, portal vein and systemic mediators. Liver products primarily influence the gut-microbiome composition and gut barrier integrity, whereas intestinal factors regulate bile acid synthesis, glucose and lipid metabolism in the liver. Alterations to gut permeability, the microbiome, and associated endotoxemia contribute to the risk of NAFLD and NASH. 2.
Also See: 7 Shocking Facts About Liver
So we can say that liver disturbance effects gut functioning and vice versa.
Here comes role of Hepza 6 syrup which not only take care of liver disorders but also regulates gut health because it contains herbs that not only act on liver but also on gut to resolve underlying cause. Mentioning few key ingredients:
a. Seabuckthorn could ameliorate high-fat diet-induced obesity and obesity-associated lipid metabolism disorders by changing the composition and structure of gut microbiota.3.
b. Cananga odorata and Cassia fistula exhibited the highest inhibitory activity, with a 72.7% and 52.7% reduction in the production of extracellular HBV DNA in comparison to the untreated control. 4.
c. Cananga odorata plant is known to possess various medicinal properties and used as traditional medicine for the treatment of malaria, asthma, gout, pneumonia, stomachache, headaches, eye inflammation, diabetes, and rheumatism. 4.
d. A. marmelos contains hepatoprotective and hypolipidemic agents, also they could be used as antioxidant agents for controlling free radicals in diabetes.5.
1. Diabetes Care 2007 Mar; 30(3): 734-743. Diabetes Care 2007 Mar; 30(3): 734-743.
2. J Hepatol. 2018 May;68(5):1063-1075. doi: 10.1016/j.jhep.2018.01.019.
3. Nutrients v.12(1); 2020 Jan PMC7020008
4. Kobe J Med Sci v.65(2); 2019 PMC7012192
5. Toxicol Rep v.5; 2018 PMC6320333
6. Hepatol Res. 2013 Jan; 43(1): 51–64.